Hello, I had an Oophorectomy procedure in April 2024. I have been on HRT consisting of estrogen and progesterone to protect my existing uterus. I have been feeling sick ever since the procedure. Nausea, severe brain fog, coughing, itching, shortness of breath, and flu-like symptoms. I noticed that micronized progesterone sets these symptoms off about 2 hours after taking it. I have tried other forms of progestins, including medroxyprogesterone and norethindrone. The itching and coughing isn’t as severe, but I still get what seems like allergic reactions. I would try an IUD, but I’m 57 and don’t feel like changing an IUD out every 5-8 years would be appropriate at my age. Are there any other options that would reduce the chances of the uterine lining building up? Thank you for any help. The doctors that I have talked to do not seem to know that progesterone/progestins can cause a histamine reaction in some people.
Endometriosis
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Endometriosis affects approximately 10% of women in Florida, impacting their daily lives and overall well-being. This chronic condition, characterized by the growth of uterine-like tissue
March 17, 2025
It’s unfortunate to hear that you’re experiencing these symptoms. You should know that these reactions are rare, which is probably why they’re often under-recognized and not well-known among many providers.
In your case, it’s important to understand why HRT was prescribed initially. It’s typically recommended for menopausal-like symptoms, which is likely why it was suggested for you. Given the side effects you’re experiencing, it’s crucial to explore non-medical approaches first. These can include lifestyle modifications such as regular physical activity and dietary changes. Herbal remedies, cognitive behavioural therapy, and acupuncture can also help alleviate menopausal symptoms and typically come with fewer side effects than HRT.
If these non-medical approaches don’t improve your symptoms and your quality of life is still affected, other approaches to HRT can be considered. One option is using cyclic progesterone, where it’s taken only part of the month, potentially reducing side effects.
If these strategies still don’t help, a hysterectomy could be discussed. While it’s a surgical procedure with some risks, it would eliminate the need for progesterone, as there would be no uterine lining to protect. Additionally, after a hysterectomy, using only estrogen therapy doesn’t increase the risk of breast cancer, which can be a concern with combined HRT.
I hope this helps you find the best option that suits you and improves your quality of life.