Endometriosis Menopause Malignancy

Can Endometriosis Become Malignant After Menopause?

Endometriosis, a condition commonly affecting women of reproductive age, doesn’t just vanish in menopause. In fact, an estimated 2-4% of postmenopausal women suffer from symptomatic endometriosis. Although endometriosis is generally benign, there lies a risk of malignant transformation. This article delves into the malignant transformation of postmenopausal endometriosis, presenting a comprehensive analysis of the topic.

Understanding Endometriosis and Menopause

Endometriosis is a complex clinical syndrome characterized by the presence of ectopic endometrial-like tissue. This pathological condition primarily affects women of reproductive age, often causing infertility and chronic pelvic pain leading to severe functional limitations.

While one might assume that the cessation of menstruation and the hypoestrogenic state associated with menopause would alleviate endometriosis, this isn’t always the case. Postmenopausal endometriosis can affect up to 4% of women. Recurrences or malignant transformations, although rare, are possible events.

Malignant Transformation: A Rare but Possible Event

While endometriosis is a benign condition, it carries a risk of malignant transformation. Approximately 1% of ovarian endometriosis can turn into cancer. However, a prospective study found a standardized incidence ratio of malignant transformation of 8.95, indicating that malignant transformation, while rare, is a serious concern.

In the case of postmenopausal endometriosis, malignant transformation is even rarer. There are no definitive percentages about its prevalence, with data derived from studies, including case reports and case series. This scarcity of data highlights the need for further research into this topic.

Recurring Clinical Conditions

In the malignant transformation of postmenopausal endometriosis, some clinical conditions tend to recur:

  • History of endometriosis
  • Definitive gynecological surgery before menopause
  • Estrogen-only hormone replacement therapy (HRT) for a relatively long time

These conditions, however, have shown a significant decrease in recent years. This decrease could be due to changes in the attitudes and management of gynecologists, influenced by up-to-date scientific evidence about the use of major surgery in gynecological pathologies.

The Role of Hormone Replacement Therapy (HRT)

HRT plays a significant role in postmenopausal endometriosis. Among the women who used HRT, estrogen-only therapy was taken by approximately 75% of women. The duration of treatment had a median of 11 years, with the course of treatment exceeding five years in most women.

Current recommendations on HRT include continuous combination formulations or Tibolone for women with previous endometriosis. However, these recommendations are based on limited data, emphasizing the need for more extensive studies on this topic.

Cancer Lesion Characteristics and Treatment

The malignant transformation of endometriosis can present with varying characteristics and may require different treatment approaches. Approximately 70% of cases had histology of endometrioid adenocarcinoma or clear cell carcinoma. The most frequent localization of the lesions was at the level of the pelvis, ovary, and vagina.

Most women underwent surgical treatment, with procedures including excision of the mass, hysterectomy with bilateral salpingo-oophorectomy, and surgical debulking. Adjuvant medical treatment was performed in about 60% of cases.

Patient Outcomes and Follow-up

The outcomes for patients with malignant transformation of postmenopausal endometriosis are generally favorable. The survival rate is approximately 80% in 12 months, with a recurrence rate of 9.8% and a death rate of 11.5%.

The duration of follow-up had a median of 12 months. However, follow-up data is still too incomplete to provide adequate information on the prognosis, highlighting the need for further research in this area.


The malignant transformation of postmenopausal endometriosis presents a clinical challenge that requires further exploration. As gynecologists’ attitudes and management strategies evolve, it’s crucial to continue research into this area, to provide accurate and individualized evaluation and information for patients.

While endometriosis is generally a benign condition, the risk of malignant transformation, particularly in postmenopausal women, should not be overlooked. Comprehensive understanding and timely management of this condition are crucial to improving patient outcomes.



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