Does Removing Endometriosis and Fibroid Tumor Increase the Chances of Pregnancy?

Overview of Endometriosis and Fibroids

Endometriosis and uterine fibroids are prevalent gynecological conditions that can profoundly impact a woman’s reproductive health and fertility. Endometriosis, affecting approximately 10% of individuals assigned female at birth (AFAB),  occurs when endometrial-like tissue is found outside of the uterus, primarily in the abdominopelvic cavity.  Fibroids, on the other hand, are non-cancerous growths made up of fibrous tissue and smooth muscle cells that develop in or around the uterus. They may also be called uterine myomas or leiomyomas and affect an estimated 20–40% of AFABs, often during their childbearing years.

While these conditions are distinct, they share some common characteristics, including the potential to cause infertility and pregnancy complications. This article aims to provide a comprehensive understanding of the effects of endometriosis and fibroids on pregnancy, as well as the various treatment options available to maintain fertility.

Endometriosis and Infertility

Endometriosis is a leading cause of infertility, responsible for approximately 50%  of infertility cases. The condition can impair fertility by obstructing the fallopian tubes, disrupting the hormonal milieu, causing inflammation, and altering endometrial development, thereby reducing the chances of successful embryo implantation.

However, it’s important to note that many individuals with endometriosis can still conceive naturally or with the assistance of fertility treatments. The impact of endometriosis on fertility may depend on the severity and location of the endometrial lesions.

Fibroids and Fertility

While fibroids are generally non-cancerous, their presence can affect fertility in several ways. Submucosal fibroids, which protrude into the uterine cavity, can significantly reduce the chances of successful embryo implantation and pregnancy rates during assisted reproductive technologies (ART) such as in vitro fertilization (IVF).

Intramural fibroids, which grow within the uterine muscle wall, can also impair fertility by distorting the uterine cavity and disrupting the hormonal environment necessary for successful implantation and placentation.

Endometriosis and Pregnancy Outcomes

People with endometriosis may face an increased risk of certain adverse pregnancy outcomes, including:

• Placental abnormalities (placenta previa, placental abruption)
• Preterm birth
• Pregnancy-induced hypertension/preeclampsia
• Cesarean delivery

The risk of these complications may be influenced by factors such as the severity of endometriosis, the presence of infertility, and the use of fertility treatments. However, many individuals with endometriosis can have successful, uncomplicated pregnancies.

Fibroids and Pregnancy Outcomes

Fibroids can also impact pregnancy outcomes in various ways. Individuals with fibroids may be at an increased risk of:

• Placental abnormalities (placental abruption, placenta previa)
• Preterm labor and delivery
• Fetal malpresentation (breech presentation)
• Cesarean delivery
• Postpartum hemorrhage

The risk of these complications may be influenced by factors such as the size, number, and location of the fibroids. Large fibroids, or those located in the uterine cavity, may pose a greater risk to the pregnancy.

Treatment Options for Fertility Preservation

For individuals with endometriosis or fibroids who desire future fertility, surgery or removal of the endometriosis lesions and/or fibroid(s)  may be recommended to improve their chances of conception and reduce the risk of pregnancy complications.

Endometriosis Surgery 

While there is no one-size-fits all approach to addressing endometriosis, surgical excision or removal of the lesions is thought to be the ideal approach to addressing the lesions directly. This minimally invasive surgery aims to remove the lesions while preserving the uterus and ovaries, allowing for future fertility.

Fibroid Removal

For individuals with fibroids who wish to maintain their fertility, a myomectomy may be recommended. This surgical procedure involves the removal of fibroids while preserving the uterus. Depending on the size, number, and location of the fibroids, myomectomies can be performed through various approaches, including:

• Hysteroscopic myomectomy (for submucosal fibroids)
• Laparoscopic myomectomy (for intramural or subserosal fibroids)
• Abdominal myomectomy (for larger or multiple fibroids)

The choice of approach depends on factors such as the size and location of the fibroids, as well as the surgeon’s expertise and the patient’s preferences.

Fertility Outcomes After Surgery

Studies have shown that those who undergo endometriosis excision or myomectomy for fibroid removal can achieve pregnancy rates ranging from 50-60%. However, it’s important to note that these procedures do not guarantee fertility, and the success rates may vary depending on factors such as age, severity of the condition, and the presence of other infertility factors.

Pregnancy Monitoring and Management

For those with endometriosis or fibroids who become pregnant, close monitoring and specialized care may be recommended to mitigate potential risks and ensure the best possible outcomes for both the mother and the baby.

This may involve regular ultrasound examinations to monitor fetal growth and placental function, as well as close monitoring for signs of preterm labor or other complications. In some cases, additional interventions or precautions may be necessary, such as bed rest, medication, or early delivery.

Non-Surgical Treatment Options

While surgical tumor removal is often the preferred option for those seeking to preserve fertility, there are also non-surgical treatment options available for managing endometriosis and fibroids. These include:

Endometriosis:

• Hormonal therapies (e.g., birth control pills, GnRH agonists)
• Anti-inflammatory medications
• Complementary therapies (e.g., dietary modifications, exercise)

Fibroids:

• Gonadotropin-releasing hormone (GnRH) agonists
• Selective progesterone receptor modulators (SPRMs)
• Uterine artery embolization (UAE)
• Magnetic resonance-guided focused ultrasound (MRgFUS)

These non-surgical options may be used to manage symptoms, reduce tumor size, or provide temporary relief before pursuing fertility treatments or tumor removal surgery.

Emerging Treatments and Future Directions

Research is ongoing to develop new and improved treatment options for endometriosis and fibroids, with a particular focus on preserving fertility and minimizing the risk of adverse pregnancy outcomes.

Some areas of active research include:

• Novel hormonal therapies and targeted therapies for endometriosis
• Improved surgical techniques for myomectomy and endometriosis excision
• Non-invasive tumor removal methods (e.g., MRgFUS, UAE)
• Preventative strategies to reduce the risk of endometriosis and fibroid development

As our understanding of these conditions continues to evolve, it is hoped that more effective and less invasive treatment options will become available, improving the quality of life and reproductive outcomes for individuals affected by endometriosis and fibroids.

Emotional and Psychological Support

The journey through endometriosis, fibroids, and infertility can be emotionally and psychologically challenging for many. It’s essential to recognize and address the emotional impact of these conditions, as well as the stress and anxiety that can accompany fertility treatments and pregnancy complications.

Support groups, counseling, and mental health resources can be invaluable in helping individuals cope with the emotional and psychological aspects of their condition and treatment. Healthcare providers should be mindful of these needs and provide appropriate referrals and support services as needed.

Conclusion

Endometriosis and fibroids are common gynecological conditions that can have a significant impact on fertility and pregnancy outcomes. While these conditions can pose challenges, there are various surgical and non-surgical options and treatment strategies available to help individuals achieve their desired family size while mitigating potential risks.

By working closely with their healthcare providers, people with endometriosis or fibroids can develop personalized treatment plans that address their individual needs and preferences. With proper management and care, those suffering from these conditions can successfully navigate pregnancy and achieve their dreams of parenthood.

REFERENCES:

https://www.uchicagomedicine.org/en/forefront/womens-health-articles/2022/august/fibroids-fertility-pregnancy

https://www.webmd.com/women/uterine-fibroids/what-if-i-have-uterine-fibroids-while-pregnant

https://www.acfs2000.com/fibroids-and-endometriosis.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608270

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187594